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Current Understanding on Opisthorchiasis: A Neglected Tropical Helminthic Zoonosis
Volume 10 | Issue 2 | December 2024
AUTHOR(S)
Mahendra Pal, Tesfaye Rebuma, Udit Jain, Priyanka Naithani, Surjit Baidya

ABSTRACT

Helminthic zoonoses are significant from public health and economic point of view. Opisthorchiasis, caused by liver flukes from the Opisthorchiidae family, represents a significant global public health challenge, particularly in Southeast Asia. With an estimated 80 million individuals at risk, the primary transmission route is the consumption of raw or undercooked freshwater fish harboring metacercariae. This review provides a comprehensive overview of the etiology, life cycle, transmission dynamics, clinical manifestations, and epidemiological patterns of opisthorchiasis. The infection is primarily linked to severe hepatobiliary complications, including cholangiocarcinoma, classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Current diagnostic methods rely on stool examination for eggs, and praziquantel remains the treatment of choice. Given the intricate life cycle involving freshwater snails and fish, effective control measures must focus on public health education, safe food practices, and enhanced surveillance.

CDC. Parasites-Opisthorchis Infection; Centres for Disease Control, Atlanta, USA. 2018.
CDC. Opisthorchiasis. Centres for Disease Control and Prevention Chttps://www.cdc.gov/dpdx/opisthorchiasis/index.html. 2023.
Chai JY. Praziquantel treatment in trematode and cestodes infections: an update. Infection and Chemotherapy. 2013; 45(1): 32-43.
Cox FE. History of human parasitology. Clinical Microbiology Reviews. 2002; 15(4): 595-612.
De Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, Plummer M. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. The Lancet Oncology. 2012; 13(6): 607-615.
Forrer A, Sayasone S, Vounatsou P, Vonghachack Y, Bouakhasith D, Vogt S, Glaser R, Utzinger J, Akkhavong K, Odermatt P. Spatial distribution of, and risk factors for, Opisthorchis viverrini infection in southern Lao PDR. PLoS Neglected Tropical Diseases. 2012; 6(2): e1481.
Garedaghi Y. A review of the importance of stool test in the diagnosis of intestinal parasites. International Journal of Medical Parasitology and Epidemiology Science, 2020; 1(2): 25-28.
Keiser J, Utzinger J. Food-borne Trematodiases. Clinical Microbiology Review, 2009; 22: 466–483.
McConnell JF. Remarks on the anatomy and pathological relations of a new species of liver-fluke. The Lancet, 1875; 106(2712): 271-274.
MSD. Opisthorchiasis. MSD Manual Professional Edition; 2023 https://www.msdmanuals.com/professional/infectious-diseases/trematodes-flukes/opisthorchiasis. Pal M. Zoonoses. Second edition. Jaipur, India: Satyam Publishers; 2007.
Pal M, Ejeta I, Girma A, Dave K, Dave P. Etiology, clinical spectrum, epidemiology, diagnosis, public health significance and control of leishmaniasis. A comprehensive review. Acta Scientific Microbiology. 2022; 5(5): 110-121.
Pal M, Gutama KP, Molnar J, Abera F, Baidya S. Giardiasis: An emerging yet neglected zoonotic disease of public health significance. Indian Journal of Veterinary Public Health. 2023; 9 (3): 16-18.
Pal M, Ketchakmadze D, Durglishvili N, Garedaghi Y. Opisthorchiasis: An emerging foodborne helminthic zoonosis of public health significance. International Journal of Medical Parasitology and Epidemiology Sciences, 2020; 1(4): 85-88.
Parkin DM, Srivatanakul P, Khlat M, Chenvidhya D, Chotiwan P, Insiripong S, L’abbé KA, Wild CP. Liver cancer in Thailand. I. A case‐control study of cholangiocarcinoma. International Journal of Cancer. 1991; 48(3): 323-328.
Petney TN, Andrews RH, Saijuntha W, Wenz-Mücke A, Sithithaworn P. The zoonotic, fish-borne liver flukes Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini. International Journal for Parasitology. 2013; 43(13): 1031-1046.
Pozio E, Armignacco O, Ferri F, Morales MA. Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union. Acta tropica. 2013; 126(1): 54-62.
Qian MB, Patel C, Palmeirim MS, Wang X, Schindler C, Utzinger J, Zhou XN, Keiser J. Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis. The Lancet Microbe. 2022; 3(8): 616-624.
Qian MB, Utzinger J, Keiser J, Zhou XN. Clonorchiasis. The Lancet. 2016; 387(20): 800-810.
Qian MB, Zhou XN. Clonorchis sinensis. Trends in Parasitology. 2021; 37(11): 1014-1015.
Saijuntha W, Duenngai K, Tangkawattana S, Petney TN, Andrews RH, Sithithaworn P. Recent advances in the diagnosis and detection of Opisthorchis viverrini sensu lato in human and intermediate hosts for use in control and elimination programs. Advances in Parasitology. 2018; 101: 177-214.
Saltykova IV, Ogorodova LM, Bragina EY, Puzyrev VP, Freidin MB. Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma. Acta Tropica. 2014; 139: 53-56.
Sayasone S, Odermatt P, Phoumindr N, Vongsaravane X, Sensombath V, Phetsouvanh R, Choulamany X, Strobel M. Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2007; 101(1):40-47.
Sithithaworn P, Andrews RH, Van De N, Wongsaroj T, Sinuon M, Odermatt P, Nawa Y, Liang S, Brindley PJ, Sripa B. The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitology International. 2012; 61(1): 10-16.
Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A. The tumorigenic liver fluke Opisthorchis viverrini–multiple pathways to cancer. Trends in parasitology. 2012a; 28(10):395-407.
Sripa B, Nawa Y, Sithithaworn P, Andrews R, Brindley PJ. Discovery of human opisthorchiasis: a mysterious history. Parasitology International. 2012b; 1(61):3-4.
Thunyaharn N, Promthet S, Wiangnon S, Suwanrungruang K, Kamsa-ard S. Survival of cholangiocarcinoma patients in northeastern Thailand after supportive treatment. Asian Pacific Journal of Cancer Prevention. 2013; 14(11):7029-7032.
Torgerson PR, Devleesschauwer B, Praet N, Speybroeck N, Willingham AL, Kasuga F, Rokni MB, Zhou XN, Fèvre EM, Sripa B, Gargouri N. World Health Organization estimates of the global and regional disease burden of 11 foodborne parasitic diseases, 2010: a data synthesis. PLoS Medicine. 2015; 12(12): e1001920.
Vinogradov A, Ishida T, Kitagawa K, Kopylov VI. Effect of strain path on structure and mechanical behavior of ultra-fine grain Cu–Cr alloy produced by equal-channel angular pressing. Acta Materialia. 2013; 53(8): 2181-2192.
WHO. Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. World Health Organization, Geneva. Available from: https://www.who.int/ publications/i/item/9789240010352. Accessed April 23, 2023.
WHO. Foodborne trematode infections. Geneva: World Health Organization. Available from: https://www.who.int/news-room/fact sheets/detail/foodborne-trematode-infections. Accessed April 15, 2022.
Wongratanacheewin S, Pumidonming W, Sermswan RW, Pipitgool V, Maleewong W. Detection of Opisthorchis viverrini in human stool specimens by PCR. Journal of Clinical Microbiology. 2002; 40 (10): 3879-3880.

DOI
https://doi.org/10.62418/ijvph.10.2.2024.26-31
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*Corresponding author’s email ID: palmahendra2@gmail.com
Citation: Pal M, Rebuma T, Jain U, Naithani P, Baidya S. Current Understanding on Opisthorchiasis: A Neglected Tropical Helminthic Zoonosis. Indian Journal of Veterinary Public Health. 2024; 10(2): 26-31.
DOI: https://doi.org/10.62418/ijvph.10.2.2024.26-31