IJVPH

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  • Online ISSN: 3048-5738
Renal Injury Induced by Bile Duct Ligation and Its Mitigation in Rat Models
Volume 10 | Issue 1 | June 2024
AUTHOR(S)
Gulzar Islam, Chitturi Pavani SS, Tanmay Halder, Rakibul Hoque, Mousumi Namasudra, Rabindra Nath Hansda, Saktipada Pradhan, Samiran Mondal

ABSTRACT

This study investigated the intricate dynamics of renal injury using the bile duct ligation (BDL) model in Sprague Dawley rats. By evaluating hematological, biochemical and histopathological parameters, we elucidated the multifaceted effects of BDL induction and subsequent treatments with Tragacanth and Natrum Sulphuricum. Hematological analysis revealed systemic changes, highlighting the broader impacts of renal dysfunction on blood composition. Biochemical assessments offered insights into renal filtration alterations associated with degenerative changes, crucial for understanding the physiological shifts in renal injury development and resolution. Histopathological examinations provided a microscopic view of structural changes and cellular responses within kidney tissue, enhancing our comprehension of renal dysfunction. Integrating BDL with Tragacanth and Natrum Sulphuricum treatments offered a valuable platform for evaluating potential therapeutic interventions. These treatments not only mitigated renal injury but also prompted further investigation into their mechanisms of action, including molecular and immunological implications. This comprehensive study significantly advanced our understanding of renal injury and suggested promising therapeutic strategies. The findings laid a robust foundation for future research aimed at refining treatment approaches and elucidating the complex mechanisms underlying renal dysfunction.

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DOI
https://doi.org/10.62418/ijvph.10.1.2024.54-60
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Corresponding author’s email ID: vetsamiran@gmail.com
Citation: Islam G, Pavani SS C, Halder T, Hoque R, Namasudra M, Hansda RN, Pradhan S, Mondal S. Renal Injury Induced by Bile Duct Ligation and Its Mitigation in Rat Models. Indian Journal of Veterinary Public Health. 2024; 10(1): 54-60.
DOI: https://doi.org/10.62418/ijvph.10.1.2024.54-60