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Comparative Histopathological Changes in Acute Toxoplasma gondii (RH Strain) Infected and Treated Mice
Volume 9 | Issue 2 | June 2023
AUTHOR(S)
Prasant Kumar Pravin, Dhananjay Kumar, Ruma Jas, Soumitra Pandit, Goutam Bordoloi, Manik Chandra Bandyopadhyay, Surajit Baidya

ABSTRACT

The aim of the present study was to investigate the comparative histopathological changes due to acute Toxoplasma gondii (RH strain) infection in infected and treated mice which might be useful observations for future research on toxoplasmosis in veterinary and medical science. Thirty Swiss albino mice were randomly divided into five equal groups (i.e. Gr. I, II, III, IV and V). The mice of group II, III, IV and V were intraperitoneally inoculated with 5×103 tachyzoites of serially passaged T. gondii, respectively). On three days post-infection (DPI) all the mice of group III, IV and V, showing the sign of acute toxoplasmosis (Ascites and respiratory distress) were treated with sulphadoxine with pyrimethamine @21.20 mg kg-1 body weight orally, azithromycin @200 mg kg-1 body weight orally and clindamycin @6 mg per mice, orally, respectively. Histopathological changes of spleen, liver, lungs and kidney of infected and treated groups were more or less similar. Spleen of Gr II, Gr III, Gr IV and Gr V revealed diffused infiltration of lymphocytes in the red pulp. Fatty degenerative changes in liver were the prominent feature in all the infected groups of mice. Lungs showed pneumonic changes and kidney showed intravascular haemolysis. Intestine of Gr III revealed perivascular cuffing of lymphocytes in submucosa and heart showed focal haemorrhages in myocardium whereas, intestine and heart of other treated groups did not reveal any significant changes.

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DOI
https://doi.org/10.62418/ijvph.9.2.2023.37-42
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Corresponding author’s email ID: dhananjaynawada87@gmail.com
Citation: Pravin PK, Kumar D, Jas R, Pandit S, Bordoloi G, Bandyopadhyay MC, Baidya S. Comparative Histopathological Changes in Acute Toxoplasma gondii (RH Strain) Infected and Treated Mice. Indian Journal of Veterinary Public Health. 2023; 9(2): 37-42.
DOI: https://doi.org/10.62418/ijvph.9.2.2023.37-42